It is now well known that microorganisms present at the skin surface are in perfect symbiosis with the skin. We can even say now that skin is made of a human and a microbial part, this is the concept of the holobiont (2). Anyway microbes are the first range of protection against external aggression causing skin aging.
Metaproteomics is able to reach in an untargeted way both human and microbial proteins together, coupled with bioinformatics and AI data processing. Based on a relative quantification of proteins between conditions made by nanoLC-MS/MS, it allows to more precisely understand what are the mechanisms involved in effects.(3) (4)
Our publication with partners (1) shows by comparison of young and aged dehydrated skins and in protection or restoration by a powerful ingredient at the taxonomic and biological functional levels .
Phylogene, founded 1999, is a biotechnology servicing company using genomics, transcriptomics, proteomics, metabolomics and bioinformatics techniques with the objective of developing methods of identification and ways to authenticate, or discover biological effects .
The applications are mainly the service to the food industry, health industry including in vitro diagnostics, cosmetics, environment industry as expertise or analysis and as kit developer to the diagnostics industry.
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