It is now well known that microorganisms present at the skin surface are in perfect symbiosis with the skin. We can even say now that skin is made of a human and a microbial part, this is the concept of the holobiont (2). Anyway microbes are the first range of protection against external aggression causing skin aging.
Metaproteomics is able to reach in an untargeted way both human and microbial proteins together, coupled with bioinformatics and AI data processing. Based on a relative quantification of proteins between conditions made by nanoLC-MS/MS, it allows to more precisely understand what are the mechanisms involved in effects.(3) (4)
Our publication with partners (1) shows by comparison of young and aged dehydrated skins and in protection or restoration by a powerful ingredient at the taxonomic and biological functional levels .
Phylogene, créée en 1999, est une société de services en biotechnologie utilisant les techniques de génomique, transcriptomique, protéomique, métabolomique et bioinformatique associée pour des applications d’identification et d’authentification ou pour mettre en évidence des effets biologiques.
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